Map3k8 ELISA Kit for Mouse(Mus musculus) | EIAab.comMap3k8 ELISA Kit for Mouse(Mus musculus)

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Map3k8 (Gene name),

Mitogen-activated protein kinase kinase kinase 8 (Protein name ), M3K8_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Map3k8(Cot;Tpl2);

Protein name:

Mitogen-activated protein kinase kinase kinase 8;

Alternative:

Proto-oncogene c-Cot;Cancer Osaka thyroid oncogene;Tumor progression locus 2(TPL-2);Serine/threonine-protein kinase cot;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms a ternary complex with NFKB1 and TNIP2.

Function:

Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

467

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

467:

LAGYFNIVRG | PPTLEYG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q07174

SMR:

Q07174

Pfam:

PF00069

KEGG:

mmu:26410

UniGene:

Mm.3275

Uniprot:

Q07174

FOR

ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

E10350h

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

E10350m

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Packing:

96T

ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

E10350r

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96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

U10350h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

U10350m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

U10350r

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96T

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

P10350Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

P10350Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8

Cat.:

P10350Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8

Protein for Mouse Mitogen-activated protein kinase kinase kinase 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The murine cot proto-oncogene: genome structure and tissue-specific expression."
Ohara R. , Miyoshi J. , Aoki M. , Toyoshima K.
Jpn. J. Cancer Res.84:518-525(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6 X CBA.
tissue: Thymus.
2.

"TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway."
Dumitru C.D. , Ceci J.D. , Tsatsanis C. , Kontoyiannis D. , Stamatakis K. , Lin J.H. , Patriotis C. , Jenkins N.A. , Copeland N.G. , Kollias G. , Tsichlis P.N.
Cell103:1071-1083(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
3.

"Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40."
Eliopoulos A.G. , Wang C.C. , Dumitru C.D. , Tsichlis P.N.
EMBO J.22:3855-3864(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CD40 AND TRAF6
4.

"NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase."
Waterfield M.R. , Zhang M. , Norman L.P. , Sun S.C.
Mol. Cell11:685-694(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKB1;TISSUE SPECIFICITY
5.

"Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner."
Das S. , Cho J. , Lambertz I. , Kelliher M.A. , Eliopoulos A.G. , Du K. , Tsichlis P.N.
J. Biol. Chem.280:23748-23757(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii."
Watford W.T. , Hissong B.D. , Durant L.R. , Yamane H. , Muul L.M. , Kanno Y. , Tato C.M. , Ramos H.L. , Berger A.E. , Mielke L. , Pesu M. , Solomon B. , Frucht D.M. , Paul W.E. , Sher A. , Jankovic D. , Tsichlis P.N. , O'Shea J.J.
J. Exp. Med.205:2803-2812(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;DISRUPTION PHENOTYPE
7.

"Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis."
Jager J. , Gremeaux T. , Gonzalez T. , Bonnafous S. , Debard C. , Laville M. , Vidal H. , Tran A. , Gual P. , Le Marchand-Brustel Y. , Cormont M. , Tanti J.F.
Diabetes59:61-70(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
8.

"TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production."
McNab F.W. , Ewbank J. , Rajsbaum R. , Stavropoulos E. , Martirosyan A. , Redford P.S. , Wu X. , Graham C.M. , Saraiva M. , Tsichlis P. , Chaussabel D. , Ley S.C. , O'Garra A.
J. Immunol.191:1732-1743(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE

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